Trials of management are inevitably long

Reply to "breakpoints and drug exposure are inevitably closely linked".

We thank Alffenaar and colleagues on their very insightful comments regarding the new breakpoints for multidrugresistant tuberculosis (MDR TB) (1). We agree that the impact of the definition goes beyond statistical increases in the prevalence of MDR TB and has a direct impact on who should be treated with first-line regimens. Revision of breakpoints implies changing the regimens on which patien...

Of Politicians and Technocrats, and Why Global Health Scholars Are Inevitably a Bit of Both: A Response to Recent Commentaries

Inevitably reborn: The reawakening of extinct innovations

In our innovation-driven world we tend to lay concepts that have lost their attractiveness to rest and rush to embrace the next giant leap. However, in most fields of creation, patterns of reawakening of old, extinct innovations can be found. It often looks as if new technological and social concepts have a life of their own, survival instincts and adaptive properties: They simply refuse to die...

Reactivation of old scars: inevitably sarcoid.

Reactivation of pre-existing scars, as a manifestation of cutaneous sarcoidosis, is uncommon and the clinical significance of this odd symptom often remains unrecognised. In the appropriate setting a skin biopsy may serve to establish the diagnosis of sarcoidosis and avoid more invasive attempts at obtaining tissue. The case of a 72 year old man with remote reactivation of multiple cutaneous sc...

Premature trial suspension will inevitably alter equipoise.

Premature Trial Suspension Will Inevitably Alter Equipoise To the Editor: The research report by the EVA-3S Investigators1 has implications which could far exceed their understandable desire to optimize safety within the trial. Following an early interim analysis, the investigators observed that the death/stroke rate after unprotected carotid angioplasty was 10.3% (6/58), as compared with 26.7%...